Display of heterologous proteins on the surface of microorganisms: From the screening of combinatorial libraries to live recombinant vaccines

@article{Georgiou1997DisplayOH,
  title={Display of heterologous proteins on the surface of microorganisms: From the screening of combinatorial libraries to live recombinant vaccines},
  author={G. Georgiou and C. Stathopoulos and P. Daugherty and A. R. Nayak and B. Iverson and R. Curtiss},
  journal={Nature Biotechnology},
  year={1997},
  volume={15},
  pages={29-34}
}
  • G. Georgiou, C. Stathopoulos, +3 authors R. Curtiss
  • Published 1997
  • Medicine, Biology
  • Nature Biotechnology
  • In recent years there has been considerable progress towards the development of expression systems for the display of heterologous polypeptides and, to a lesser extent, oligosaccharides on the surface of bacteria or yeast. The availability of protein display vectors has in turn provided the impetus for a range of exciting technologies. Polypepttde libraries can be displayed in bacteria and screened by cell sorting techniques, thus simplifying the isolation of proteins with high affinity for… CONTINUE READING

    Topics from this paper.

    Microbial cell-surface display.
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