Displacement of tight junction proteins from detergent-resistant membrane domains by treatment with sodium caprate.

We have investigated the effect of sodium salt of capric acid (C10) on major tight junction proteins such as claudin and occludin, and also examined the involvement of lipid rafts with C10-induced alterations on these proteins. We firstly examined the C10 effect on the barrier function of tight junctions by measuring transepithelial electrical resistance… CONTINUE READING