Displacement of corticotropin releasing factor from its binding protein as a possible treatment for Alzheimer's disease

@article{Behan1995DisplacementOC,
  title={Displacement of corticotropin releasing factor from its binding protein as a possible treatment for Alzheimer's disease},
  author={Dominic P. Behan and Stephen C. Heinrichs and Juan C. Troncoso and Xin-jun Liu and Claudia H. Kawas and Nicholas C. Ling and Errol B. de Souza},
  journal={Nature},
  year={1995},
  volume={378},
  pages={284-287}
}
IN Alzheimer's disease (AD) there are dramatic reductions in the content of corticotropin releasing factor (CRF)1–4, reciprocal increases in CRF receptors1,2, and morphological abnormalities in CRF neurons5 in affected brain areas. Cognitive impairment in AD patients is associated with a lower cerebrospinal fluid concentration of CRF6, which is known to induce increases in learning and memory in rodents7–9. This suggests that CRF deficits contribute to cognitive impairment. The identification… 

Corticotropin-releasing factor antagonists, binding-protein and receptors: implications for central nervous system disorders.

A role for CRF binding sites in co-ordinating stress reactivity, emotionality and energy balance over the life-span of the organism is supported.

Corticotropin releasing factor-binding protein (CRF-BP) as a potential new therapeutic target in Alzheimer’s disease and stress disorders

The key evidence for and against the involvement of stress-associated modulation of the CRF system in the pathogenesis of Alzheimer's disease are summarized and how recent findings could lead to new potential treatment possibilities in Alzheimer’s disease by using CRF-BP as a therapeutic target is discussed.

Corticotropin-Releasing Factor (CRF) and Endocrine Responses to Stress: CRF Receptors, Binding Protein, and Related Peptides

  • A. TurnbullC. Rivier
  • Biology
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1997
Recent findings with respect to CRF, its receptors, binding protein, and CRF-related peptides are described, which provide further insights into the role and mechanisms of CRF action in stress responses.

Corticotropin Releasing Factor Binding Protein as a Novel Target to Restore Brain Homeostasis: Lessons Learned From Alcohol Use Disorder Research

A narrative review focuses on molecular mechanisms related to the role of CRFBP in the progression of addictive and psychiatric disorders, biological aging, and age-related neurodegenerative disease.
...

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