Displacement of albumin-bound antimicrobial agents by bilirubin.

  title={Displacement of albumin-bound antimicrobial agents by bilirubin.},
  author={D. Bratlid and T. Bergan},
  volume={14 5},
The ability of bilirubin to displace antimicrobial agents from their binding sites on albumin was studied in vitro by equilibrium dialysis. Sulfonamides, tetracyclines, penicillins and cephalosporins of different degrees of protein binding were tested. It was found that bilirubin reduced the protein binding of all four classes of antimicrobial agents, although by varying degrees. This effect was most pronounced with the compounds which had the highest degree of protein binding, such as… Expand
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