Displacement of 3H-EKC binding by opioids in rat kidney: a correlate to diuretic activity.

@article{Slizgi1985DisplacementO3,
  title={Displacement of 3H-EKC binding by opioids in rat kidney: a correlate to diuretic activity.},
  author={G R Slizgi and James H. Ludens},
  journal={Life sciences},
  year={1985},
  volume={36 23},
  pages={
          2189-93
        }
}
Multiple opioid binding sites have been documented in brain tissue. In this study we report on the presence of binding sites for the opioid ethylketocyclazocine (EKC) in a membrane fraction of rat kidney. Binding appeared to be selective in that opioids varied markedly in their capacities to displace 3H-EKC. Correlating with the capacity of an opioid to displace 3H-EKC was the ability to produce diuresis. Although our studies cannot assign a particular physiological or pharmacological role for… CONTINUE READING