Displacement Whiplash PCR: Optimized Architecture and Experimental Validation

Abstract

Whiplash PCR-based methods of biomolecular computation (BMC), while highly-versatile in principle, are well-known to suffer from a simple but serious form of self-poisoning known as back-hybridization. In this work, an optimally re-engineered WPCR-based architecture, Displacement Whiplash PCR (DWPCR) is proposed and experimentally validated. DWPCR’s new… (More)
DOI: 10.1007/11925903_31

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