Dispersal of Biofilms by Secreted, Matrix Degrading, Bacterial DNase

  title={Dispersal of Biofilms by Secreted, Matrix Degrading, Bacterial DNase},
  author={Reindert Nijland and Michael J Hall and J Grant Burgess},
  booktitle={PloS one},
Microbial biofilms are composed of a hydrated matrix of biopolymers including polypeptides, polysaccharides and nucleic acids and act as a protective barrier and microenvironment for the inhabiting microbes. While studying marine biofilms, we observed that supernatant produced by a marine isolate of Bacillus licheniformis was capable of dispersing bacterial biofilms. We investigated the source of this activity and identified the active compound as an extracellular DNase (NucB). We have shown… CONTINUE READING
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Development and characterization of a subtilin-regulated expression system in Bacillus subtilis: strict control of gene expression by addition of subtilin

  • RS Bongers, JW Veening, M Van Wieringen, OP Kuipers, M Kleerebezem
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