Dispensability of mammalian DNA.

  title={Dispensability of mammalian DNA.},
  author={Cory Y McLean and Gill Bejerano},
  journal={Genome research},
  volume={18 11},
In the lab, the cis-regulatory network seems to exhibit great functional redundancy. Many experiments testing enhancer activity of neighboring cis-regulatory elements show largely overlapping expression domains. Of recent interest, mice in which cis-regulatory ultraconserved elements were knocked out showed no obvious phenotype, further suggesting functional redundancy. Here, we present a global evolutionary analysis of mammalian conserved nonexonic elements (CNEs), and find strong evidence to… CONTINUE READING
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