Disparity of innate immunity-related gene effects on asthma and allergy on Karelia.

@article{Zhang2011DisparityOI,
  title={Disparity of innate immunity-related gene effects on asthma and allergy on Karelia.},
  author={Guicheng Zhang and Pierre V. Candelaria and Johanna M M{\"a}kel{\"a} and S Khoo and M Catherine Hayden and Leena C von Hertzen and Tiina E. Laatikainen and Erkki Vartiainen and Jack Goldblatt and Tari Haahtela and N Peter LeSou{\"e}f},
  journal={Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology},
  year={2011},
  volume={22 6},
  pages={621-30}
}
BACKGROUND We investigated the interactive effects of 11 innate immunity-related genes (IL10, IL12b, IL8, TLR2, TLR4, CD14, IFNGR, CC16, IFNg, CMA1, and TGFB) and four IgE response genes (IL4, IL13, IL4RA, and STAT6) with 'Western' or 'Eastern' environments/lifestyles on asthma and allergy in Karelian children. METHODS Karelian children (412 Finnish and 446 Russian) were recruited and assessed for a range of allergic conditions, with 24 single-nucleotide polymorphisms genotyped in 15 genes… CONTINUE READING
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