Disparity between tonic and phasic ethanol-induced dopamine increases in the nucleus accumbens of rats.

@article{Robinson2009DisparityBT,
  title={Disparity between tonic and phasic ethanol-induced dopamine increases in the nucleus accumbens of rats.},
  author={Donita L Robinson and Elaina Charlotte Howard and Scott R. McConnell and Rueben A. Gonzales and R Mark Wightman},
  journal={Alcoholism, clinical and experimental research},
  year={2009},
  volume={33 7},
  pages={
          1187-96
        }
}
BACKGROUND Dopamine concentrations in the nucleus accumbens fluctuate on phasic (subsecond) and tonic (over minutes) timescales in awake rats. Acute ethanol increases tonic concentrations of dopamine, but its effect on subsecond dopamine transients has not been fully explored. METHODS We measured tonic and phasic dopamine fluctuations in the nucleus accumbens of rats in response to ethanol (within-subject cumulative dosing, 0.125 to 2 g/kg, i.v.). RESULTS Microdialysis samples yielded… CONTINUE READING
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