Disparity between proximal and distal airway reactivity during methacholine challenge.

  title={Disparity between proximal and distal airway reactivity during methacholine challenge.},
  author={Leopoldo N Segal and Roberta M Goldring and Beno W. Oppenheimer and Alexandra Stabile and Joan Reibman and William Rom and Michael D. Weiden and Kenneth I Berger},
  volume={8 3},
There is an increasing awareness of the role of distal airways in the pathophysiology of obstructive lung diseases including asthma and chronic obstructive pulmonary disease. We hypothesize that during induced bronchoconstriction: 1) disparity between distal and proximal airway reactivity may occur; and 2) changes in distal airway function may explain symptom onset in subjects with minimal FEV(1) change. 185 subjects underwent methacholine challenge testing (MCT). In addition to spirometry… CONTINUE READING
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