Disparate temporal expression of the prothrombin and thrombin receptor genes during mouse development.

@article{Soifer1994DisparateTE,
  title={Disparate temporal expression of the prothrombin and thrombin receptor genes during mouse development.},
  author={Scott J. Soifer and Kevin G. Peters and John O'Keefe and Shaun R Coughlin},
  journal={The American journal of pathology},
  year={1994},
  volume={144 1},
  pages={60-9}
}
The protease thrombin is a potent agonist for platelet aggregation, mesenchymal cell proliferation, and endothelial production of growth factors and adhesion molecules. Thrombin also modulates neurite outgrowth in neuronal cultures. These apparently disparate responses to thrombin appear to be largely mediated by the recently cloned thrombin receptor. In the adult, thrombin is generated from its zymogen prothrombin at sites of vascular injury when circulating coagulation factors meet… CONTINUE READING
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