Disparate roles for TNF-alpha and Fas ligand in concanavalin A-induced hepatitis.

@article{Ksontini1998DisparateRF,
  title={Disparate roles for TNF-alpha and Fas ligand in concanavalin A-induced hepatitis.},
  author={Rached Ksontini and Donato Colagiovanni and M D Josephs and Carl Keith Edwards and Cynthia L. Tannahill and Carmen C. Sol{\'o}rzano and Jim Norman and Woody Denham and Michael J Clare-Salzler and Sally L. D. Mackay and Lyle L. Moldawer},
  journal={Journal of immunology},
  year={1998},
  volume={160 8},
  pages={4082-9}
}
Apoptosis is a physiologic process that serves to eliminate cells during development or in response to immunologic regulation. In acute inflammation, however, apoptosis triggered by the overproduction of "death factors" such as TNF-alpha or Fas ligand (FasL) may contribute to tissue injury. Both TNF-alpha and FasL are presumed to convey an apoptotic signal by activating a cascade of cysteine-aspartate proteases, which includes IL-1beta-converting enzyme or caspase-1. In the present study, we… CONTINUE READING