Disparate proteins use similar architectures to damage membranes.

  title={Disparate proteins use similar architectures to damage membranes.},
  author={Gregor Anderluh and Jeremy H Lakey},
  journal={Trends in biochemical sciences},
  volume={33 10},
Membrane disruption can efficiently alter cellular function; indeed, pore-forming toxins (PFTs) are well known as important bacterial virulence factors. However, recent data have revealed that structures similar to those found in PFTs are found in membrane active proteins across disparate phyla. Many similarities can be identified only at the 3D-structural level. Of note, domains found in membrane-attack complex proteins of complement and perforin (MACPF) resemble cholesterol-dependent… CONTINUE READING

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