Disparate proteins use similar architectures to damage membranes.

@article{Anderluh2008DisparatePU,
  title={Disparate proteins use similar architectures to damage membranes.},
  author={Gregor Anderluh and Jeremy H Lakey},
  journal={Trends in biochemical sciences},
  year={2008},
  volume={33 10},
  pages={482-90}
}
Membrane disruption can efficiently alter cellular function; indeed, pore-forming toxins (PFTs) are well known as important bacterial virulence factors. However, recent data have revealed that structures similar to those found in PFTs are found in membrane active proteins across disparate phyla. Many similarities can be identified only at the 3D-structural level. Of note, domains found in membrane-attack complex proteins of complement and perforin (MACPF) resemble cholesterol-dependent… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 84 references

Crystal structure of the MACPF domain of human complement protein C8a in complex with the C8g subunit

Slade, D.J
J. Mol. Biol • 2008

Molecular determinants of sphingomyelin specificity of a eukaryotic pore forming toxin

B Bakrač
J. Biol • 2008

Thermodynamics of the interactions of tryptophan-rich cathelicidin antimicrobial peptides with model and natural membranes

Andrushchenko, V.V
Biochim. Biophys. Acta • 2008

Tilted peptides: a structural motif involved in protein membrane insertion?

Journal of peptide science : an official publication of the European Peptide Society • 2008

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