Disparate Role of LIGHT in Organ-specific Donor T Cells Activation and Effector Molecules in MHC Class II Disparate GVHD

Abstract

The present studies determined the role of LIGHT on organ-specific cytokine and effector molecules in acute graft-versus-host disease. Cytokine and effector molecules were assessed by flow cytometry and quantitative PCR. More CD4+ spleen cells (SpC) expressing interferon-γ (IFNγ) and interleukin-2 were noted in SpC isolated from lethally irradiated bm12 X… (More)
DOI: 10.1007/s10875-009-9337-1

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