Disorganized Innervation and Neuronal Loss in the Inner Ear of Slitrk6-Deficient Mice

@inproceedings{Katayama2009DisorganizedIA,
  title={Disorganized Innervation and Neuronal Loss in the Inner Ear of Slitrk6-Deficient Mice},
  author={Kei-Ichi Katayama and Azel Zine and Maya Ota and Yoshifumi Matsumoto and Takashi Inoue and Bernd Fritzsch and Jun Aruga},
  booktitle={PloS one},
  year={2009}
}
Slitrks are type I transmembrane proteins that share conserved leucine-rich repeat domains similar to those in the secreted axonal guidance molecule Slit. They also show similarities to Ntrk neurotrophin receptors in their carboxy-termini, sharing a conserved tyrosine residue. Among 6 Slitrk family genes in mammals, Slitrk6 has a unique expression pattern, with strong expression in the sensory epithelia of the inner ear. We generated Slitrk6-knockout mice and investigated the development of… CONTINUE READING