Disorganization of the splenic microanatomy in ageing mice.

@article{Aw2016DisorganizationOT,
  title={Disorganization of the splenic microanatomy in ageing mice.},
  author={D. Abdul Latiff Aw and Lucy Hilliard and Yoshio Nishikawa and Emma Tamsin Cadman and Rachel A. Lawrence and Donald B. Palmer},
  journal={Immunology},
  year={2016},
  volume={148 1},
  pages={
          92-101
        }
}
The precise mechanisms responsible for immunosenescence still remain to be determined, however, considering the evidence that disruption of the organization of primary and secondary lymphoid organs results in immunodeficiency, we propose that this could be involved in the decline of immune responses with age. Therefore, we investigated the integrity of the splenic microarchitecture in mice of increasing age and its reorganization following immune challenge in young and old mice. Several… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 56 REFERENCES

The role of senescent cells in ageing

JM vanDeursen
  • Nature
  • 2014

The effect of age on thymic function. Frontiers in immunology

DB Palmer
  • 2013

The effect of age on thymic function. Frontiers in immunology

DB Palmer
  • 2013