Disorders of the Aldosterone Synthase and Steroid 11β-Hydroxylase Deficiencies

  title={Disorders of the Aldosterone Synthase and Steroid 11β-Hydroxylase Deficiencies},
  author={M. Peter and J. M. Dubuis and W. Sippell},
  journal={Hormone Research in Paediatrics},
  pages={211 - 222}
  • M. Peter, J. M. Dubuis, W. Sippell
  • Published 1999
  • Medicine
  • Hormone Research in Paediatrics
  • The most potent corticosteroids are 11β-hydroxylated compounds. In humans, two cytochrome P450 isoenzymes with 11β-hydroxylase activity, catalysing the biosynthesis of cortisol and aldosterone, are present in the adrenal cortex. CYP11B1, the gene encoding 11β-hydroxylase (P450c11), is expressed on high levels in the zona fasciculata and is regulated by ACTH. CYP11B2, the gene encoding aldosterone synthase (P450c11Aldo), is expressed in the zona glomerulosa under primary control of the renin… CONTINUE READING
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