Disorders in cell circuitry during multistage carcinogenesis: the role of homeostasis.

  title={Disorders in cell circuitry during multistage carcinogenesis: the role of homeostasis.},
  author={I. Bernard Weinstein},
  volume={21 5},
The multistage process of carcinogenesis involves the progressive acquisition of mutations, and epigenetic abnormalities in the expression, of multiple genes that have highly diverse functions. An important group of these genes are involved in cell cycle control. Thus, cyclin D1 is frequently overexpressed in a varety of human cancers. Cylin D1 plays a critical role in carcinogenesis because (i) overexpression enhances cell transformation and tumorigenesis, and enhances the amplification of… CONTINUE READING


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