Disordered water within a hydrophobic protein cavity visualized by x-ray crystallography.

@article{Yu1999DisorderedWW,
  title={Disordered water within a hydrophobic protein cavity visualized by x-ray crystallography.},
  author={Bo Yu and Michael Blaber and Angela M. Gronenborn and G Marius Clore and Donald L. D. Caspar},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 1},
  pages={103-8}
}
Water in the hydrophobic cavity of human interleukin 1beta, which was detected by NMR spectroscopy but was invisible by high resolution x-ray crystallography, has been mapped quantitatively by measurement and phasing of all of the low resolution x-ray diffraction data from a single crystal. Phases for the low resolution data were refined by iterative density modification of an initial flat solvent model outside the envelope of the atomic model. The refinement was restrained by the condition… CONTINUE READING

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