Disordered proteins and network disorder in network descriptions of protein structure, dynamics and function: hypotheses and a comprehensive review.

@article{Csermely2012DisorderedPA,
  title={Disordered proteins and network disorder in network descriptions of protein structure, dynamics and function: hypotheses and a comprehensive review.},
  author={P{\'e}ter Csermely and Kuljeet Singh Sandhu and Eszter Hazai and Zsolt Hoksza and Huba J. M. Kiss and Federico Miozzo and Daniel V. Veres and Francesco Piazza and Ruth Nussinov},
  journal={Current protein \& peptide science},
  year={2012},
  volume={13 1},
  pages={
          19-33
        }
}
During the last decade, network approaches became a powerful tool to describe protein structure and dynamics. Here we review the links between disordered proteins and the associated networks, and describe the consequences of local, mesoscopic and global network disorder on changes in protein structure and dynamics. We introduce a new classification of protein networks into 'cumulus-type', i.e., those similar to puffy (white) clouds, and 'stratus-type', i.e., those similar to flat, dense (dark… Expand
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