Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes.

@article{Lewis2002DisorderedFS,
  title={Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes.},
  author={Gary F. Lewis and Andr{\'e} C Carpentier and Khosrow Adeli and Adria Giacca},
  journal={Endocrine reviews},
  year={2002},
  volume={23 2},
  pages={201-29}
}
The primary genetic, environmental, and metabolic factors responsible for causing insulin resistance and pancreatic beta-cell failure and the precise sequence of events leading to the development of type 2 diabetes are not yet fully understood. Abnormalities of triglyceride storage and lipolysis in insulin-sensitive tissues are an early manifestation of conditions characterized by insulin resistance and are detectable before the development of postprandial or fasting hyperglycemia. Increased… CONTINUE READING
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