Disordered Sleep, Nocturnal Cytokines, and Immunity in Alcoholics

  title={Disordered Sleep, Nocturnal Cytokines, and Immunity in Alcoholics},
  author={Laura S. Redwine and Jeff Dang and Martica H. Hall and Michael R. Irwin},
  journal={Psychosomatic Medicine},
Objective Alcoholics who are at risk for infectious disease show profound disturbances of sleep along with decrements of cellular immunity. This study examined the relationships between sleep, nocturnal expression of immunoregulatory cytokines, and natural killer (NK) cell activity in alcoholic patients as compared with control subjects. Methods Alcoholic patients (N = 24) and comparison control subjects (N = 23) underwent all-night polysomnography and serial blood sampling at 23:00, 03:00, and… 

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