Disordered Sleep, Nocturnal Cytokines, and Immunity in Alcoholics

  title={Disordered Sleep, Nocturnal Cytokines, and Immunity in Alcoholics},
  author={L. Redwine and Jeff Dang and M. Hall and M. Irwin},
  journal={Psychosomatic Medicine},
  • L. Redwine, Jeff Dang, +1 author M. Irwin
  • Published 2003
  • Medicine, Psychology
  • Psychosomatic Medicine
  • Objective Alcoholics who are at risk for infectious disease show profound disturbances of sleep along with decrements of cellular immunity. This study examined the relationships between sleep, nocturnal expression of immunoregulatory cytokines, and natural killer (NK) cell activity in alcoholic patients as compared with control subjects. Methods Alcoholic patients (N = 24) and comparison control subjects (N = 23) underwent all-night polysomnography and serial blood sampling at 23:00, 03:00, and… CONTINUE READING
    81 Citations
    Nocturnal proinflammatory cytokine-associated sleep disturbances in abstinent African American alcoholics
    • 76
    Inflammatory Markers and Sleep Disturbance in Major Depression
    • 249
    • PDF
    Disordered sleep, nocturnal cytokines, and immunity: interactions between alcohol dependence and African-American ethnicity.
    • 12
    • PDF
    Leptin and cellular and innate immunity in abstinent alcoholics and controls.
    • 18
    • PDF
    Sleep depth and fatigue: Role of cellular inflammatory activation
    • 60
    • Highly Influenced
    • PDF
    Sleep associated regulation of T helper 1/T helper 2 cytokine balance in humans
    • 149
    The association between interleukin-6, sleep, and demographic characteristics
    • 73


    Circadian interleukin-6 secretion and quantity and depth of sleep.
    • 388
    • PDF
    Elevation of plasma cytokines in disorders of excessive daytime sleepiness: role of sleep disturbance and obesity.
    • 860
    • PDF
    Effects of Sleep on the Production of Cytokines in Humans
    • 110
    Effects of sleep and circadian rhythm on human circulating immune cells.
    • 463
    Partial night sleep deprivation reduces natural killer and celhdar immune responses in humans
    • 409
    Nocturnal plasma levels of cytokines in healthy men
    • 75
    Cytokines as Regulators of Sleep a
    • 60
    • Highly Influential
    Effects of sleep and sleep deprivation on interleukin-6, growth hormone, cortisol, and melatonin levels in humans.
    • 346
    • PDF
    Immune function in alcoholism: a controlled study.
    • 46
    • PDF
    Acute effects of recombinant human interleukin-6 on endocrine and central nervous sleep functions in healthy men.
    • 383
    • PDF