Disorder-specific effects of polymorphisms at opposing ends of the Insulin Degrading Enzyme gene

@inproceedings{Bartl2011DisorderspecificEO,
  title={Disorder-specific effects of polymorphisms at opposing ends of the Insulin Degrading Enzyme gene},
  author={Jasmin Bartl and Claus-J{\"u}rgen Scholz and Margareta Hinterberger and Susanne Jungwirth and Ildiko Wichart and Michael Rainer and Susanne Kneitz and Walter Danielczyk and Karl Heinz Tragl and Peter Fischer and Peter Franz Riederer and Edna Gr{\"u}nblatt},
  booktitle={BMC Medical Genetics},
  year={2011}
}
Insulin-degrading enzyme (IDE) is the ubiquitously expressed enzyme responsible for insulin and amyloid beta (Aβ) degradation. IDE gene is located on chromosome region 10q23-q25 and exhibits a well-replicated peak of linkage with Type 2 diabetes mellitus (T2DM). Several genetic association studies examined IDE gene as a susceptibility gene for Alzheimer's… CONTINUE READING