Disopyramide serum and pharmacologic effect kinetics applied to the assessment of bioavailability.

@article{Bryson1978DisopyramideSA,
  title={Disopyramide serum and pharmacologic effect kinetics applied to the assessment of bioavailability.},
  author={S. M. Bryson and Brian Whiting and James Robert Lawrence},
  journal={British journal of clinical pharmacology},
  year={1978},
  volume={6 5},
  pages={409-19}
}
1 Serum, urine and pharmacologic effect (prolongation of the QT interval) kinetics of the antiarrhythmic disopyramide have been investigated in eight volunteers after intravenous administration (2 mg/kg) and oral administration (300 mg) of the two commercially available preparations, Rythmodan (Roussel Laboratories) and Norpace (Searle Laboratories). 2 An open one compartment body model adequately described the kinetics of disopyramide in serum and urine. 3 After intravenous administration, the… CONTINUE READING