Dismantling the germinal center: comparing the processes of transformation, regression, and fragmentation of the lymphoid follicle.

@article{Jones2002DismantlingTG,
  title={Dismantling the germinal center: comparing the processes of transformation, regression, and fragmentation of the lymphoid follicle.},
  author={Dan Jones},
  journal={Advances in anatomic pathology},
  year={2002},
  volume={9 2},
  pages={
          129-38
        }
}
The pathologic and immunologic features of the formation of the germinal center have been extensively studied. The process of dissolution of the germinal center is not as well understood. Different patterns of germinal-center breakdown are commonly encountered in diagnostic lymph node biopsy specimens and frequently present difficulties in diagnosis. The current immunologic understanding of germinal-center dynamics is reviewed and correlated with the histologic and immunophenotypic features of… CONTINUE READING

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