Disintegrins from Snake Venoms and their Applications in Cancer 
Research and Therapy

@article{Macdo2015DisintegrinsFS,
  title={Disintegrins from Snake Venoms and their Applications in Cancer 
Research and Therapy},
  author={J{\'e}ssica K A Mac{\^e}do and J. Fox and M. S. Castro},
  journal={Current Protein \& Peptide Science},
  year={2015},
  volume={16},
  pages={532 - 548}
}
Integrins regulate diverse functions in cancer pathology and in tumor cell development and contribute to important processes such as cell shape, survival, proliferation, transcription, angiogenesis, migration, and invasion. A number of snake venom proteins have the ability to interact with integrins. Among these are the disintegrins, a family of small, non-enzymatic, and cysteine-rich proteins found in the venom of numerous snake families. The venom proteins may have a potential role in terms… Expand
Effects of Animal Venoms and Toxins on Hallmarks of Cancer
Cell migration inhibition activity of a non-RGD disintegrin from Crotalus durissus collilineatus venom
Kinome scale profiling of venom effects on cancer cells reveals potential new venom activities.
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