Disintegrins from Hematophagous Sources

  title={Disintegrins from Hematophagous Sources},
  author={Teresa Cristina F Assumpç{\~a}o and Jose M. C. Ribeiro and Ivo M B Francischetti},
Bloodsucking arthropods are a rich source of salivary molecules (sialogenins) which inhibit platelet aggregation, neutrophil function and angiogenesis. Here we review the literature on salivary disintegrins and their targets. Disintegrins were first discovered in snake venoms, and were instrumental in our understanding of integrin function and also for the development of anti-thrombotic drugs. In hematophagous animals, most disintegrins described so far have been discovered in the salivary… CONTINUE READING
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