Disinhibitory effect of phencyclidine in the hippocampus in vitro: PCP receptors implicated.

@article{Bourne1988DisinhibitoryEO,
  title={Disinhibitory effect of phencyclidine in the hippocampus in vitro: PCP receptors implicated.},
  author={G. W. Bourne and Brandt Esplin and Radan {\vC}apek},
  journal={European journal of pharmacology},
  year={1988},
  volume={150 1-2},
  pages={67-74}
}
The effects of phencyclidine (PCP) and two dioxolane stereoisomers, dexoxadrol and levoxadrol, on hippocampal inhibition were compared. Field potentials were recorded in the CA1 pyramidal cell layer in the rat hippocampal slices in vitro. Recurrent inhibition of the population spikes evoked orthodromically by stimulation of the Schaffer collaterals was induced by antidromic conditioning stimulation at appropriate time intervals before the orthodromic stimulation. The drugs were applied by… CONTINUE READING