Disinhibition of somatostatin-positive GABAergic interneurons results in an anxiolytic and antidepressant-like brain state

@inproceedings{Fuchs2016DisinhibitionOS,
  title={Disinhibition of somatostatin-positive GABAergic interneurons results in an anxiolytic and antidepressant-like brain state},
  author={Thomas Fuchs and Sarah J. Jefferson and A Hooper and P-Hp Yee and Jaime L Maguire and Bernhard Luscher},
  booktitle={Molecular Psychiatry},
  year={2016}
}
Major depressive disorder (MDD) is associated with reduced concentrations of γ-aminobutyric acid (GABA) that are normalized by antidepressant therapies. Moreover, depressive-like phenotypes of GABAA receptor mutant mice can be reversed by treatment with conventional antidepressants drugs, as well as by subanesthetic doses of ketamine. Thus GABAergic deficits may causally contribute to depressive disorders, while antidepressant therapies may enhance GABAergic synaptic transmission. Here we… CONTINUE READING
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