Disinhibition Bursting of Dopaminergic Neurons

  title={Disinhibition Bursting of Dopaminergic Neurons},
  author={Collin J. Lobb and Todd W. Troyer and Charles J. Wilson and Carlos A. Paladini},
  booktitle={Front. Syst. Neurosci.},
Substantia nigra pars compacta (SNpc) dopaminergic neurons receive strong tonic inputs from GABAergic neurons in the substantia nigra pars reticulata (SNpr) and globus pallidus (GP), and glutamatergic neurons in the subthalamic nucleus. The presence of these tonic inputs raises the possibility that phasic disinhibition may trigger phasic bursts in dopaminergic neurons. We first applied constant NMDA and GABA(A) conductances onto a two-compartment single cell model of the dopaminergic neuron… CONTINUE READING