Soluble squalamine tablets for the rapid disinfection of home nebulizers of cystic fibrosis patients.
INTRODUCTION Nebulization may transport with the drug some small particles containing microbes. STATE OF THE ART These microbes may be present in all parts of the nebulizer, including the drug solution itself. Depending on the studies, contamination of the nebulizers may reach up to 55% of the devices in patients with cystic fibrosis. That's why using one nebulizer for one patient, using drug sterile ampoules, and having a good hygiene during and after the nebulization are so important. The national disinfection recommendations, usually depending on the type of the nebulizer, are variable from one to another country and are not very well validated. Moreover, the repetitive use of these disinfection techniques on the performances of the nebulizer are neither studied. In daily life, the patients respect these disinfection recommendations in 3 to 98% of the cases. PERSPECTIVES We propose a standardized methodology for evaluating the microbial and functional effects of all disinfectants on the nebulizers. CONCLUSION A simple, quick, efficacious, cheap, and without effect on nebulizer performances disinfectant is still waiting.