Disialoganglioside GD2 on human neuroblastoma cells: target antigen for monoclonal antibody-mediated cytolysis and suppression of tumor growth.

@article{Mujoo1987DisialogangliosideGO,
  title={Disialoganglioside GD2 on human neuroblastoma cells: target antigen for monoclonal antibody-mediated cytolysis and suppression of tumor growth.},
  author={K Mujoo and David A. Cheresh and Hsin Ming Yang and Ralph A. Reisfeld},
  journal={Cancer research},
  year={1987},
  volume={47 4},
  pages={1098-104}
}
A murine monoclonal antibody 14.18 specifically recognizes disialoganglioside GD2, the major ganglioside expressed on the surface of human neuroblastoma cells. This monoclonal antibody (Mab) is of immunoglobulin G3 isotype, has an affinity constant (KA) of 3.5 X 10(8) M-1, and reacts preferentially with tumor cells and fresh frozen tumor tissues of neuroectodermal origin in enzyme-linked immunosorbent assay and immunoperoxidase assays, respectively. Mab 14.18 effectively lyses a number of human… CONTINUE READING
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Murine monoclonal antibody (Mab) specific for GD2 ganglioside. A Phase I trial in patients with neuroblastoma, mela noma, and osteogenic sarcoma

  • N. V. Cheung, N. Berger, +5 authors S. Strandjord
  • Proc. Am. Assoc. Cancer Res.,
  • 1986
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