Dishevelled proteins are significantly upregulated in chronic lymphocytic leukaemia

@article{Khan2016DishevelledPA,
  title={Dishevelled proteins are significantly upregulated in chronic lymphocytic leukaemia},
  author={Abdul Salam Khan and Mohammad Hojjat-Farsangi and Amir Hossein Daneshmanesh and Lotta Hansson and Parviz Kokhaei and Anders {\"O}sterborg and H{\aa}kan Mellstedt and Ali Z. Moshfegh},
  journal={Tumor Biology},
  year={2016},
  volume={37},
  pages={11947-11957}
}
Dishevelled (DVL) proteins are components of the Wnt signalling pathways, and increased expression is associated with various malignancies. Information on DVLs in chronic lymphatic leukaemia (CLL) is limited. The aim of the present study was to investigate the role of DVLs in CLL cells and association with Wnt pathways downstream of ROR1. DVL1, 2 and 3 were exclusively expressed in CLL cells as compared to normal peripheral blood mononuclear cells (PBMCs). The expression of DVL1 and DVL3… CONTINUE READING
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