Dishevelled promotes neurite outgrowth in neuronal differentiating neuroblastoma 2A cells, via a DIX-domain dependent pathway.

@article{Fan2004DishevelledPN,
  title={Dishevelled promotes neurite outgrowth in neuronal differentiating neuroblastoma 2A cells, via a DIX-domain dependent pathway.},
  author={Shongshan Fan and Servio H. Ramirez and Tatiana M. Garcia and Stephen Dewhurst},
  journal={Brain research. Molecular brain research},
  year={2004},
  volume={132 1},
  pages={38-50}
}
Dishevelled (Dvl) is a cytoplasmic protein involved in the Wnt-Frizzled signaling cascade, which has also been shown to interact with the cytoskeleton in part through inhibition of glycogen synthase kinase 3beta (GSK3beta). Using mouse neuroblastoma 2A (N2A) cells as a model system, we have found that overexpression of Dvl promotes the outgrowth of neurite-like processes, and leads to the induction of a striking, bipolar morphologic phenotype during neuronal differentiation. In contrast… CONTINUE READING
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