Dishevelled activates Ca2+ flux, PKC, and CamKII in vertebrate embryos

  title={Dishevelled activates Ca2+ flux, PKC, and CamKII in vertebrate embryos},
  author={Laird C. Sheldahl and Diane C Slusarski and Petra Pandur and Jeffrey R. Miller and Michael K{\"u}hl and Randall T. Moon},
  journal={The Journal of Cell Biology},
  pages={769 - 777}
Wnt ligands and Frizzled (Fz) receptors have been shown to activate multiple intracellular signaling pathways. Activation of the Wnt-beta-catenin pathway has been described in greatest detail, but it has been reported that Wnts and Fzs also activate vertebrate planar cell polarity (PCP) and Wnt-Ca2+ pathways. Although the intracellular protein Dishevelled (Dsh) plays a dual role in both the Wnt-beta-catenin and the PCP pathways, its potential involvement in the Wnt-Ca2+ pathway has not been… CONTINUE READING
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