Disgust in pre-clinical Huntington's disease: A longitudinal study

@article{Sprengelmeyer2006DisgustIP,
  title={Disgust in pre-clinical Huntington's disease: A longitudinal study},
  author={Reiner Sprengelmeyer and Ulrike Schroeder and Andrew W. Young and J{\"o}rg T. Epplen},
  journal={Neuropsychologia},
  year={2006},
  volume={44},
  pages={518-533}
}

The Processing of Emotion in Patients With Huntington's Disease: Variability and Differential Deficits in Disgust

The findings support the view that impairment in the recognition of disgusted facial expressions may reflect processes involving the central aspects of disgust knowledge.

Disgust and Huntington's disease

Beyond disgust: impaired recognition of negative emotions prior to diagnosis in Huntington's disease.

Examination of emotion recognition in Huntington's disease found no evidence of relative impairments in recognizing disgust or fear, and no evidence to support a link between the striatum and disgust recognition.

Social cognition in Huntington’s disease: A meta-analysis

Production of spontaneous and posed facial expressions in patients with Huntington's disease: Impaired communication of disgust

The findings suggest that a common substrate might participate in both the processing and the expression of this emotion in patients with Huntington's disease.

Early Dysfunction of Neural Transmission and Cognitive Processing in Huntington’s Disease

It is not uncommon for HD patients to become aware of their own disease rather late into its progression when motor symptoms begin to emerge, and for children of patients often avoid determining their genotype because of legitimate fears of employment discrimination or difficulties maintaining health insurance.
...

References

SHOWING 1-10 OF 41 REFERENCES

Impaired recognition of disgust in Huntington's disease gene carriers.

People who were free from clinical symptoms and did not perform significantly more poorly than non-carriers on any of the background tests, on any other face processing tasks, and even for recognition of any other basic emotion points strongly to the importance of the basal ganglia in the emotion of disgust.

Neural correlates associated with impaired disgust processing in pre-symptomatic Huntington's disease.

The finding of dysfunctional decreased insula activation in pre-symptomatic Huntington's disease provides an explanation for the clinical deficit in recognizing facial expression of disgust and underscores the role of the insula in the emotion of disgust.

Recognition of facial expressions : Selective impairment of specific emotions in Huntington's disease

Recognition of facial expressions of basic emotions was investigated in HL and UJ, two people with Huntington's disease who showed little evidence of general cognitive deterioration. No impairments

The distribution of structural neuropathology in pre-clinical Huntington's disease.

Evidence of distributed grey matter pathology and progressive white matter atrophy with age before clinical onset of Huntington's disease is provided, suggesting that VBM may be useful in monitoring cross-sectional and longitudinal changes in brain structure in pre-clinical Huntington’s disease and for determining the efficacy of neuroprotective agents.

Loss of disgust. Perception of faces and emotions in Huntington's disease.

Face perception and emotion recognition were investigated in a group of people with Huntington's disease and matched controls, showing that the recognition of some emotions is more impaired than others and disgust is a prime candidate.

Emotion comprehension in the temporal variant of frontotemporal dementia.

The data indicate that tvFTD is associated with impairments in emotional processing that may underlie some behavioural problems in this disorder, and that the emergence of such deficits depends on the specific pattern of anatomical injury.

Huntington disease

The Commission for the Control of Huntington Disease and Its Consequences, established by the Ninety-Fourth United States Congress, recently completed an appraisal of clinical care of the patient and family with Huntington disease.