Disequilibrium of M1 and M2 Macrophages Correlates with the Development of Experimental Inflammatory Bowel Diseases

@article{Zhu2014DisequilibriumOM,
  title={Disequilibrium of M1 and M2 Macrophages Correlates with the Development of Experimental Inflammatory Bowel Diseases},
  author={Wei Zhu and Jianbo Yu and Ying Nie and Xuekui Shi and Yang Liu and Fujuan Li and Xiaoli Zhang},
  journal={Immunological Investigations},
  year={2014},
  volume={43},
  pages={638 - 652}
}
Ulcerative colitis, a major inflammatory bowel disease, is an idiopathic inflammatory disorder of the colonic mucosa, accompanied by an aberrant immune reaction to intestinal microflora. Macrophages are central mediators of intestinal immune homeostasis and inflammation. The relationship between macrophages and the pathogenesis of colitis is poorly understood. We aimed to characterize the changing populations and roles of M1/M2 macrophages in colitis. We demonstrated that M1 macrophages… 

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