Disentangling the microRNA regulatory milieu in multiple myeloma: integrative genomics analysis outlines mixed miRNA-TF circuits and pathway-derived networks modulated in t(4;14) patients.

@article{Calura2016DisentanglingTM,
  title={Disentangling the microRNA regulatory milieu in multiple myeloma: integrative genomics analysis outlines mixed miRNA-TF circuits and pathway-derived networks modulated in t(4;14) patients.},
  author={Enrica Calura and Andrea Bisognin and Martina Manzoni and Katia Todoerti and Elisa Taiana and Gabriele Sales and Gareth J Morgan and Giovanni Tonon and Nicola Amodio and Pierfrancesco Tassone and Antonino Neri and Luca Agnelli and Chiara Romualdi and Stefania Bortoluzzi},
  journal={Oncotarget},
  year={2016},
  volume={7 3},
  pages={2367-78}
}
The identification of overexpressed miRNAs in multiple myeloma (MM) has progressively added a further level of complexity to MM biology. miRNA and gene expression profiles of two large representative MM datasets, available from retrospective and prospective series and encompassing a total of 249 patients at diagnosis, were analyzed by means of in silico integrative genomics methods, based on MAGIA2 and Micrographite computational procedures. We first identified relevant miRNA/transcription… CONTINUE READING
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Integrated analysis of microRNAs, transcription factors and target genes expression discloses a specific molecular architecture of hyperdiploid multiple myeloma

  • MT Di Martino, PH Guzzi, +7 authors P. Tagliaferri
  • Oncotarget
  • 2015
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