Disentangling polydispersity in the PCNA−p15PAF complex, a disordered, transient and multivalent macromolecular assembly

@inproceedings{Cordeiro2017DisentanglingPI,
  title={Disentangling polydispersity in the PCNA−p15PAF complex, a disordered, transient and multivalent macromolecular assembly},
  author={Tiago N Cordeiro and Po-chia Chen and Alfredo De Biasio and Nathalie Sibille and Francisco J Blanco and Jochen S. Hub and Ramon Crehuet and Pau Bernad{\'o}},
  booktitle={Nucleic acids research},
  year={2017}
}
The intrinsically disordered p15PAF regulates DNA replication and repair when interacting with the Proliferating Cell Nuclear Antigen (PCNA) sliding clamp. As many interactions between disordered proteins and globular partners involved in signaling and regulation, the complex between p15PAF and trimeric PCNA is of low affinity, forming a transient complex that is difficult to characterize at a structural level due to its inherent polydispersity. We have determined the structure, conformational… CONTINUE READING
3
Twitter Mentions

Citations

Publications citing this paper.
SHOWING 1-6 OF 6 CITATIONS

Complementary uses of small angle X-ray scattering and X-ray crystallography.

VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

The role of small-angle scattering in structure-based screening applications

VIEW 7 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Interpreting solution X-ray scattering data using molecular simulations.

  • Jochen S. Hub
  • Biology, Medicine
  • Current opinion in structural biology
  • 2018
VIEW 2 EXCERPTS
CITES METHODS

p15PAF binding to PCNA modulates the DNA sliding surface

VIEW 2 EXCERPTS
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 90 REFERENCES

Dynamics of Open DNA Sliding Clamps.

VIEW 1 EXCERPT