Disentangling normal aging from Alzheimer's disease in structural magnetic resonance images.

@article{Lorenzi2015DisentanglingNA,
  title={Disentangling normal aging from Alzheimer's disease in structural magnetic resonance images.},
  author={Marco Lorenzi and Xavier Pennec and Giovanni B. Frisoni and Nicholas Ayache},
  journal={Neurobiology of aging},
  year={2015},
  volume={36 Suppl 1},
  pages={S42-52}
}
The morphology observed in the brains of patients affected by Alzheimer's disease (AD) is a combination of different biological processes, such as normal aging and the pathological matter loss specific to AD. The ability to differentiate between these biological factors is fundamental to reliably evaluate pathological AD-related structural changes, especially in the earliest phase of the disease, at prodromal and preclinical stages. Here we propose a method based on non-linear image… CONTINUE READING
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We therefore define the longitudinal model of normal aging in the template

  • Lorenzi, Pennec
  • 2013

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