Disentangling genetic and environmental risk factors for individual diseases from multiplex comorbidity networks

  title={Disentangling genetic and environmental risk factors for individual diseases from multiplex comorbidity networks},
  author={Peter Klimek and Silke Aichberger and Stefan Thurner},
  journal={Scientific Reports},
Most disorders are caused by a combination of multiple genetic and/or environmental factors. If two diseases are caused by the same molecular mechanism, they tend to co-occur in patients. Here we provide a quantitative method to disentangle how much genetic or environmental risk factors contribute to the pathogenesis of 358 individual diseases, respectively. We pool data on genetic, pathway-based, and toxicogenomic disease-causing mechanisms with disease co-occurrence data obtained from almost… 

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