Diseases of the neuromuscular junction.

  title={Diseases of the neuromuscular junction.},
  author={John McConville and Angela Vincent},
  journal={Current opinion in pharmacology},
  volume={2 3},
The neuromuscular junction is a prototype synapse and it is also the site of well-characterised autoimmune and hereditary disorders. In the presynaptic terminal, voltage-gated potassium channels and voltage-gated calcium channels are subtly altered in genetic disorders and mutations in the enzyme that synthesises acetylcholine have been demonstrated in a particular form of hereditary myasthenia syndrome. Recent advances have revealed agrin, muscle-specific kinase (MuSK) and rapsyn as important… CONTINUE READING


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