Diseases of the nervous system: Of blood and brain


Protective tumor microenvironments can induce resistance to otherwise effective antibody-based anticancer therapies. Adding the chemotherapeutic cyclophosphamide to the treatment can render resistant leukemia cells sensitive to immunity-mediated killing by remodeling the tumor cell surroundings in the bone marrow (Cell 156, 560–602, 2014). Using a humanized… (More)
DOI: 10.1038/nm.3505