Disease-specific target selection: a critical first step down the right road.

@article{Roses2005DiseasespecificTS,
  title={Disease-specific target selection: a critical first step down the right road.},
  author={A. D. Roses and Daniel K. Burns and Stephanie L. Chissoe and L Robert Middleton and Pamela St. Jean},
  journal={Drug discovery today},
  year={2005},
  volume={10 3},
  pages={177-89}
}
Relevance of a drug target for a disease is often inferred with strong belief but fragile evidence. Here, a program for early identification of human disease-specific drug targets using high-throughput genetic associations is described. Large numbers of well-characterized patients (>1000) and matched controls are screened for genetic associations using several thousand (>7000) single nucleotide polymorphisms from more than 1500 genes. The genes were selected because they are members of target… CONTINUE READING
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