Disease-specific gene repositioning in breast cancer

  title={Disease-specific gene repositioning in breast cancer},
  author={Karen J. Meaburn and Prabhakar R. Gudla and Sameena Khan and Stephen J. Lockett and Tom Misteli},
  booktitle={The Journal of cell biology},
Genomes are nonrandomly organized within the three-dimensional space of the cell nucleus. Here, we have identified several genes whose nuclear positions are altered in human invasive breast cancer compared with normal breast tissue. The changes in positioning are gene specific and are not a reflection of genomic instability within the cancer tissue. Repositioning events are specific to cancer and do not generally occur in noncancerous breast disease. Moreover, we show that the spatial positions… CONTINUE READING