Disease-specific eQTL screening reveals an anti-fibrotic effect of AGXT2 in nonalcoholic fatty liver disease

@article{Yoo2021DiseasespecificES,
  title={Disease-specific eQTL screening reveals an anti-fibrotic effect of AGXT2 in nonalcoholic fatty liver disease},
  author={Taekyeong Yoo and Sae Kyung Joo and Hyo Jung Kim and Hyun Young Kim and Hyungtai Sim and Jieun Lee and Hee-Hoon Kim and Sunhee Jung and Youngha Lee and Oveis Jamialahmadi and Stefano Romeo and Won-Il Jeong and Geum-Sook Hwang and Keon Wook Kang and Jae Woo Kim and Won Kim and Murim Choi},
  journal={bioRxiv},
  year={2021}
}
Background & Aims Nonalcoholic fatty liver disease (NAFLD) poses an impending clinical burden. Genome-wide association studies have revealed a limited contribution of genomic variants to the disease, requiring alternative but robust approaches to identify disease-associated variants and genes. We carried out a disease-specific expression quantitative trait loci (eQTL) screen to identify novel genetic factors that specifically act on NAFLD progression on the basis of genotype. Methods We… 
Metabolic dysfunction-associated fatty liver disease: advances in genetic and epigenetic implications
TLDR
The latest developments in the field of NAFLD-genomics can be leveraged for identifying novel disease mechanisms and therapeutic targets that may prevent the morbidity and mortality associated with disease progression.

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