Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia

@article{Mirnics2001DiseasespecificCI,
  title={Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia},
  author={K{\'a}roly Mirnics and Frank A. Middleton and Gregg David Stanwood and David A. Lewis and Pat Levitt},
  journal={Molecular Psychiatry},
  year={2001},
  volume={6},
  pages={293-301}
}
Complex defects in neuronal signaling may underlie the dysfunctions that characterize schizophrenia. Using cDNA microarrays, we discovered that the transcript encoding regulator of G-protein signaling 4 (RGS4) was the most consistently and significantly decreased in the prefrontal cortex of all schizophrenic subjects examined. The expression levels of ten other RGS family members represented on the microarrays were unchanged and hierarchical data analysis revealed that as a group, 274 genes… CONTINUE READING
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