Disease-specific biomarker discovery by aptamers.

  title={Disease-specific biomarker discovery by aptamers.},
  author={Henning Ulrich and Carsten Wrenger},
  journal={Cytometry. Part A : the journal of the International Society for Analytical Cytology},
  volume={75 9},
RNA and DNA aptamers developed by an in vitro selection process, Systematic Evolution of Ligands by EXponential enrichment (SELEX), comprise a novel class of high-affinity and specific capture agents, which can be easily modified for cytometry and in vivo applications. A novel application of this technique (Cell SELEX) explores the expression of cell surface epitopes that differ between two given cell types or between healthy and diseased cells. Using whole cells as targets, aptamer libraries… CONTINUE READING


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