Disease severity is associated with differential gene expression at the early and late phases of infection in nonhuman primates infected with different H5N1 highly pathogenic avian influenza viruses.

@article{Muramoto2014DiseaseSI,
  title={Disease severity is associated with differential gene expression at the early and late phases of infection in nonhuman primates infected with different H5N1 highly pathogenic avian influenza viruses.},
  author={Yukiko Muramoto and Jason E. Shoemaker and Mai thi Quynh Le and Yasushi Itoh and Daisuke Tamura and Yuko Sakai-Tagawa and Hirotaka Imai and Ryuta Uraki and Ryo Takano and Eiryo Kawakami and Mutsumi Bunkyo-ku Ito and Kiyoko Okamoto and Hirohito Ishigaki and Hitomi Mimuro and Chihiro Sasakawa and Yukiko Matsuoka and Takeshi Noda and Satoshi Fukuyama and Kazumasa Ogasawara and Hiroaki Kitano and Yoshihiro Kawaoka},
  journal={Journal of virology},
  year={2014},
  volume={88 16},
  pages={
          8981-97
        }
}
UNLABELLED Occasional transmission of highly pathogenic avian H5N1 influenza viruses to humans causes severe pneumonia with high mortality. To better understand the mechanisms via which H5N1 viruses induce severe disease in humans, we infected cynomolgus macaques with six different H5N1 strains isolated from human patients and compared their pathogenicity and the global host responses to the virus infection. Although all H5N1 viruses replicated in the respiratory tract, there was substantial… CONTINUE READING
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